There are two attitudes toward life that are possible, and you can have only one or the other.
One attitude is to save your life now: hoard it, clutch it, cling to it, grasp it, try to get hold of it for yourself, take care of yourself, trust yourself, see that in every situation your first and major concern is,
What's in it for me? That is one way to live, and millions are living that way today.
The other attitude is lose it: fling it away, disregard what advantage there may be for you in a situation, and move out in dependence upon God, careless of what may happen to you. Abraham obeyed God, went out into a land he knew not where, on a march without a map, apparently careless of what would happen to him. His neighbors reproached and rebuked him for not caring about himself. This is to be a way of life, Jesus says. Trust God, obey Him, and put the responsibility for what happens on Him.
"But lose your life for My sake and the gospel's," says Jesus, lose your life by means of giving yourself away in the cause of Christ, giving up your right to yourself, taking up your cross and following Me, and you will save it. You will not waste it, but you will save it. You will find contentment and satisfaction, an inner peace, and a sense of worth about your living. You will discover, not just in heaven someday but right now, that even though you may not have all the things others have, your life will be rich and rewarding and satisfying.
[Excerpt from Ray Stedman: Saving or Losing]